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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

4 min

How does volume of distribution change with age?

The volume of distribution (Vd) is a crucial pharmacokinetic parameter that indicates how a drug distributes between the plasma and other tissues in the body. As individuals age, significant shifts in body composition and organ function occur, causing Vd to change dramatically and necessitating dosage adjustments to ensure safety and effectiveness.

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4 min

Which pharmacokinetic process is most affected by age?

Pharmacokinetics, the study of how the body absorbs, distributes, metabolizes, and excretes drugs, is significantly altered by the aging process. While age impacts all four of these processes to some extent, the most clinically significant changes often occur in drug elimination and metabolism, which can profoundly influence medication safety and efficacy for older adults.

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