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What is Sam's disease? Understanding Segmental Arterial Mediolysis (SAM)

First described in 1976, Segmental Arterial Mediolysis (SAM) is a rare and often overlooked vascular disease with an unknown etiology. To understand what is Sam's disease, one must recognize that it is a non-inflammatory and non-atherosclerotic condition that leads to weakening and damage of arterial walls, most commonly in the abdomen.