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What does a hole in the bone mean?

According to the Bone Health & Osteoporosis Foundation, over 54 million Americans are at risk for osteoporosis, a condition that can cause bones to become porous with holes like a sponge. For those concerned about their skeletal health, the question of "what does a hole in the bone mean" is a serious one, as it can be a sign of many underlying conditions, ranging from benign to severe.