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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

4 min

Does Denosumab Affect Fracture Healing? Understanding the Mechanism and Evidence

While early concerns existed that antiresorptive drugs could inhibit bone repair, clinical evidence, including findings from the pivotal FREEDOM trial, indicates that denosumab does not delay fracture healing. However, its mechanism of action profoundly affects the bone remodeling phase, a critical step in the long-term strength of a healed fracture.

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4 min

How does calcitonin work to treat osteoporosis?

Osteoporosis affects millions of aging adults worldwide, leading to brittle bones susceptible to fractures. For certain individuals, calcitonin offers a unique treatment option by targeting the cells that break down bone. But how does calcitonin work to treat osteoporosis at a fundamental, cellular level? This guide explores the precise biological mechanisms behind this important therapy.

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3 min

What is OPG Osteoporosis and How Does It Affect Bone Health?

According to the International Osteoporosis Foundation, over 200 million people worldwide are affected by osteoporosis, a condition characterized by low bone mass and bone fragility. The bone-preserving protein known as Osteoprotegerin (OPG) is central to this disease, as it plays a crucial role in preventing bone loss by regulating the body's natural bone-resorbing processes. Understanding what is OPG osteoporosis is key to grasping the molecular mechanisms that either maintain strong bones or contribute to their deterioration.

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3 min

The Paradox of Decreased Parathyroid Hormone Level: How It Can Increase Bone Mineral Density While Increasing Fracture Risk

Contrary to the assumption that low parathyroid hormone (PTH) levels cause osteoporosis, research shows that a decrease in PTH, a condition known as hypoparathyroidism, typically results in paradoxically higher bone mineral density (BMD). However, this denser bone is often brittle and can increase the risk of certain fractures due to poor bone quality. This article clarifies how a decreased parathyroid hormone level impacts bone health in unexpected ways.

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4 min

Exploring the Vital Role: What is the function of calcitonin in bone?

Bone is a living tissue that is constantly remodeled throughout life, a process regulated by several hormones. A key player in this process, calcitonin, is a hormone whose primary function is to regulate and maintain the delicate balance of bone density and blood calcium levels.

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4 min

Does Calcitonin Affect Osteoporosis? Understanding Its Role and Efficacy

Calcitonin is a hormone that can affect osteoporosis by slowing bone loss and increasing bone mineral density, though its use as a primary treatment has declined. In fact, the FDA has limited its use for postmenopausal osteoporosis to patients for whom other treatments are unsuitable due to its lower efficacy compared to other drug classes and a potential link to cancer with long-term use.

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4 min

What are the phases of Paget's disease?

According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, Paget's disease of the bone is a chronic condition affecting bone remodeling that can alter the structure of bones over time. Understanding **what are the phases of Paget's disease** is a critical first step toward effective management and maintaining quality of life during healthy aging.

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4 min

Understanding Normal Changes: Does ALP Go Up with Age?

Over the course of a lifetime, our bodies undergo numerous physiological changes, and our blood biomarkers are no exception. Among these, alkaline phosphatase (ALP) is one enzyme whose levels fluctuate significantly throughout the aging process, peaking in old age after childhood and adolescence. Understanding these natural shifts is crucial for interpreting blood test results accurately as you age.

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4 min

Are bone remodeling and repair lifelong processes?

The human skeleton is a dynamic and active organ, not an inert structure, constantly renewing and reshaping its living tissue throughout your entire lifespan. This continuous renewal confirms that, yes, **are bone remodeling and repair lifelong processes** essential for maintaining skeletal integrity and overall health.

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