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Does norepinephrine increase or decrease with age?

According to decades of research, studies have found significant increases in resting plasma norepinephrine levels in healthy older adults compared to younger individuals. This heightened presence of norepinephrine, a key neurotransmitter and hormone, raises the question: does norepinephrine increase or decrease with age, and what are the implications for the body's stress response and overall health? This article delves into the complex changes within the noradrenergic system as we age, examining how altered production, clearance, and receptor function contribute to elevated circulating levels.