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Chronic, low-grade inflammation, or “inflammaging,” is a hallmark of aging and contributes significantly to age-related disease. An emerging area of research is investigating the pro-inflammatory cytokine interleukin-11 (IL-11) to answer the profound question: is IL-11 a master regulator of ageing?
Studies have revealed that aging is associated with a dysregulation of the cytokine network, leading to a progressive pro-inflammatory state. This is commonly referred to as 'inflammaging,' and elevated levels of interleukin-6 (IL-6) are a well-documented marker, indicating that yes, IL-6 does increase with age.
According to research published in *BMC Geriatrics*, elevated inflammation is a notable characteristic in older adults, correlating with the progression of frailty. The process by which inflammation contributes to frailty is complex, involving multiple physiological systems and the dysregulation of the body's immune response over time. Chronic, low-grade inflammation, often termed 'inflammaging,' creates a pro-inflammatory state that accelerates cellular aging and functional decline.
According to scientific research, chronic, low-grade systemic inflammation is often a feature of osteoporosis. The relationship between bone biology and inflammatory processes is far more intricate than once thought, and it can significantly influence how osteoporosis develops and progresses.
Recent studies suggest that levels of certain cytokines, including Transforming Growth Factor-beta (TGF-β), do indeed increase with age. This age-related elevation is linked to various physiological changes and can contribute to conditions associated with the aging process.
