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Healthy Aging Hub

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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

5 min

Why are older adults frequently needing careful titration of their drug doses?

As people age, a number of physiological changes occur, influencing how medications are handled by the body. These natural shifts mean that older adults are not simply smaller versions of younger adults when it comes to medication, which is why older adults are frequently needing careful titration of their drug doses.

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5 min

How Does Aging Affect Renal Elimination of Drugs?

On average, glomerular filtration rate (GFR) begins to decline after age 40, a key factor in how does aging affect renal elimination of drugs? This natural physiological change profoundly impacts medication metabolism and safety in older adults, necessitating careful management.

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4 min

How does volume of distribution change with age?

The volume of distribution (Vd) is a crucial pharmacokinetic parameter that indicates how a drug distributes between the plasma and other tissues in the body. As individuals age, significant shifts in body composition and organ function occur, causing Vd to change dramatically and necessitating dosage adjustments to ensure safety and effectiveness.

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