Why is progestin used in menopausal hormone therapy? The critical role of endometrial protection
For women taking systemic estrogen therapy who still have their uterus, combining it with a progestogen can significantly reduce the risk of endometrial cancer. Progestin is used in menopausal hormone therapy primarily to counteract the proliferative effect of estrogen on the uterine lining, preventing a condition that could otherwise lead to cancer. This crucial protective role ensures the safety of combined hormone therapy for millions of women seeking relief from menopausal symptoms.