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Which age-related pharmacokinetic change to the GI system does the older adult patient experience?

According to research, age-related changes occur in all parts of the pharmacokinetic process, influencing how medications are absorbed, distributed, metabolized, and eliminated. Specifically, older adults experience several pharmacokinetic changes to the GI system, which can significantly affect drug absorption and overall medication efficacy and safety. These changes include altered gastric acidity, reduced motility, and decreased blood flow, which collectively can alter a medication's bioavailability.