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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

5 min

What are the 9 markers of aging? An in-depth guide

In a 2013 review published in the journal *Cell*, researchers identified and categorized nine key processes, known as the 'hallmarks of aging,' that drive the aging process across various organisms. These interconnected markers, from genomic instability to altered intercellular communication, represent the cellular and molecular changes that lead to the progressive decline of physiological function. Understanding **what are the 9 markers of aging** is crucial for developing therapies to promote healthy aging and combat age-related diseases.

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4 min

Unpacking the Science: Why Does Mortality Increase with Age?

In adult humans, the risk of death doubles approximately every eight years, a pattern known as the Gompertz law. This exponential increase prompts a critical question: why does mortality increase with age? The answer lies in a complex interplay of genetic, cellular, and systemic changes that accumulate over a lifetime.

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5 min

How does age affect tissue repair and mutations?

Aging is the single biggest risk factor for the decline of regenerative capacity and the accumulation of genetic mutations throughout a lifetime. Understanding precisely how age affects tissue repair and mutations is a central focus of geroscience, providing critical insights into the biological underpinnings of age-related disease.

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4 min

The 12 Cellular Pillars and Hallmarks of Aging

In 2023, scientists expanded the framework of aging research by identifying and updating the list of key biological processes that drive the aging process. While the original 2013 list identified nine core factors, this updated model now includes 12 cellular pillars, or hallmarks, of aging that explain the progressive decline in physiological integrity.

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4 min

How does DNA repair change during aging?

Every cell in the human body faces thousands of DNA damage events daily from both internal and external sources. Our body's DNA repair machinery works tirelessly to fix this damage, but with age, this process changes and becomes less efficient. Understanding how does DNA repair change during aging is crucial for unlocking the mysteries of age-related disease and longevity.

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5 min

What is the most common cause of aging? Unpacking the hallmarks of senescence

Aging is a complex biological process influenced by multiple factors, with a 2024 study by Stanford Medicine researchers finding that massive biomolecular shifts occur in our bodies around ages 40 and 60. So, what is the most common cause of aging? Modern science suggests there is no single cause, but rather a cascade of interconnected cellular and molecular changes that progressively lead to the decline of function over time.

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4 min

Biology & Genetics: What goes first with age?

Recent studies suggest that, for many gene expressions, age can be a more significant factor than genetics, especially after age 55. So, what goes first with age? From a biological and genetic perspective, the process begins subtly, with cellular mechanisms that control repair and function slowly faltering over time.

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4 min

Who gets the Werner syndrome? An overview of this rare genetic disorder

Werner syndrome, sometimes called "adult progeria," is a rare autosomal recessive genetic disorder, estimated to affect 1 in 200,000 individuals in the United States. To answer the question, **Who gets the Werner syndrome?**, a look into the underlying genetics and inheritance pattern is required.

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6 min

Decoding the Biology: What are the five stages of aging?

Though often perceived through visible markers like wrinkles and gray hair, human aging is a complex biological process that starts much earlier at the cellular level. Understanding **what are the five stages of aging** from a genetic perspective provides a deeper look into the molecular mechanisms driving our decline over time.

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4 min

What is the final stage of aging?: A Biological and Genetic Perspective

Genetics play a significant role in determining lifespan, with studies showing that inherited factors account for up to 25% of the variation in human longevity. So, what is the final stage of aging, and how do biological and genetic mechanisms culminate in this irreversible decline?

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