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Is Gliosis Age Related? The Complex Link Between Aging and Glial Scars

Recent studies indicate that gliosis, the proliferation and hypertrophy of glial cells, is often an intensified response in aged brains compared to younger ones. While the exact mechanisms are still being explored, an age-related increase in reactive gliosis has been documented following nervous system injuries and in the context of neurodegenerative diseases. This suggests that the aging process significantly influences how glial cells behave, potentially shifting their function from supportive to more pro-inflammatory.