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Understanding What Is the Effect of Aging on the HPG Axis?

With organismal aging, activity in the hypothalamic–pituitary–gonadal (HPG) axis gradually declines, leading to systemic functional reductions in target tissues. Understanding what is the effect of aging on the HPG axis is key to addressing the hormonal shifts that impact health span and overall well-being. This complex interplay of hormonal changes is a natural part of the aging process, impacting both men and women.