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What happened to the corpus callosum in late adulthood?: Explaining Age-Related Brain Changes

According to one longitudinal study, atrophy of the corpus callosum is a predictor of progressive cognitive and motor impairment in elderly subjects. When considering what happened to the corpus callosum in late adulthood, research consistently shows that this critical bridge of white matter connecting the two brain hemispheres experiences significant structural and microstructural decline as part of the normal aging process.