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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

5 min

What are the markers of senescent macrophages?

Cellular senescence, a hallmark of aging, affects various cell types, including immune cells like macrophages. An accumulation of these non-proliferating but metabolically active senescent macrophages contributes significantly to age-related decline and chronic inflammation. But what are the specific markers that define this cellular state?

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4 min

How Does Aging Affect Macrophages and Immunosenescence?

Chronic low-grade inflammation, known as 'inflammaging,' is a hallmark of aging. Central to this process are macrophages, innate immune cells whose function undergoes significant and detrimental changes with advancing age, ultimately contributing to age-related diseases.

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4 min

What Happens to Red Blood Cells When They Age?

With an average lifespan of about 120 days, human red blood cells (RBCs) undergo a series of progressive changes that signal their eventual removal from circulation. As red blood cells age, their membranes become more rigid, and their metabolic activity declines, marking them for clearance by specialized immune cells. This natural process, known as erythrocyte senescence, is a vital part of maintaining blood homeostasis.

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4 min

Do Macrophages Decrease with Age? Understanding the Shifting Immune Landscape

While the total number of immune cells in the body remains relatively stable throughout life, the composition and functionality of specific immune cell types, including macrophages, change with age. This complex shift means that while total macrophage count might not decrease across all tissues, their function and distribution are profoundly altered, leading to a state of chronic, low-grade inflammation known as "inflammaging". Recent studies have revealed a significant reduction in macrophage function, such as phagocytosis and migration, in older individuals compared to younger ones.

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4 min

What are the effects of Ageing on monocytes and macrophages?

Globally, chronic, low-grade inflammation is a hallmark of aging, a phenomenon known as inflammaging. The effects of ageing on monocytes and macrophages are central to this process, driving systemic inflammation and contributing to age-related decline.

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