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What is the least significant change in BMD?

According to the International Society for Clinical Densitometry (ISCD), the least significant change (LSC) is a precision value used to determine if a measured bone mineral density (BMD) difference between two Dual-Energy X-ray Absorptiometry (DXA) exams is statistically significant. An understanding of what is the least significant change in BMD is essential for distinguishing a true biological change from a random measurement error. Without knowing the LSC, clinicians risk misinterpreting bone density fluctuations, which could lead to inappropriate patient management.