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What is antipsychotic polypharmacy? An overview of risks, benefits, and guidelines

With global median rates hovering around 20% in schizophrenia patients, antipsychotic polypharmacy (APP) is a common but debated practice in clinical psychiatry. In its most common form, **antipsychotic polypharmacy** refers to the concurrent use of two or more antipsychotic medications for an individual patient. While typically discouraged by treatment guidelines in favor of monotherapy, it is a strategy sometimes employed for managing difficult-to-treat symptoms.