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How does aging affect the process of protein folding in cells?

By middle age, the activity of the proteasome, a major protein-degrading complex, can decline in several mammalian tissues. This age-related deterioration is a key part of understanding **how does aging affect the process of protein folding in cells**, a critical process known as proteostasis. The decline in cellular maintenance compromises the cell's ability to produce properly folded, functional proteins, and efficiently remove damaged ones.