Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.
Over six decades of use as a diabetes medication have revealed metformin's remarkable properties extending beyond blood sugar control. This growing body of evidence has led to the question: why is metformin called the youth drug?
While animal studies have consistently shown that rapamycin can extend lifespan and healthspan, reviews of human trials reveal limited evidence to support these claims in healthy adults. The drug, originally an immunosuppressant, has become a focal point in longevity research for its ability to inhibit the mTOR pathway, a key cellular process linked to aging. However, the translation of benefits seen in mice and other organisms to humans remains uncertain and unproven.
Global longevity research shows that delaying age-related diseases could significantly extend human healthspan. In this quest for extending human healthspan, the question of what is the most promising anti-aging drug captures significant scientific and public interest.
Scientists have identified that protein levels in the blood can predict a person's age within a three-year range, pointing to a direct link between protein changes and the aging process. But more specifically, many proteins are associated with aging, including key regulators like Lamin A, p53, and the mTOR pathway, which influence cellular health, DNA repair, and overall longevity.
According to research on model organisms and emerging human studies, calorie restriction (CR) has been shown to extend lifespan and improve healthspan, highlighting the fundamental question: **What is the calorie restriction mechanism of aging?** This process involves sophisticated cellular and genetic responses that shift the body into a state of heightened resilience and repair.
Harvard biologist David Sinclair follows a diet and lifestyle regimen focused on activating the body's natural defense mechanisms against aging. Understanding what is David Sinclair's diet reveals a strategic approach to eating and fasting, rather than just a list of foods, designed to promote cellular health and longevity.
