:

What is likely a key underlying mechanism that contributes both directly and indirectly to frailty?

According to extensive research, chronic, low-grade inflammation, known as 'inflammaging,' is a primary suspect in the physiological decline associated with aging, positioning it as a key underlying mechanism that contributes both directly and indirectly to frailty. This persistent inflammatory state is distinct from acute inflammation and can have a systemic, detrimental impact on health.