Which cell decreases in activity with age? The role of immunosenescence and neurogenesis.
T-cell development and the replenishment of naive T-cell pools decline dramatically with age, impacting the body's ability to mount new immune responses. This decline is just one example of how multiple cell types, including hematopoietic and neural stem cells, experience a decrease in activity with age, leading to broader systemic effects like increased vulnerability to disease and cognitive decline.