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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

Oct 21, 2025

3 min

Is Senescence-Associated β-galactosidase (SA-β-gal) a Marker of Neuronal Senescence?

Over the last two decades, the field of aging has seen extensive research into cellular senescence, a process marked by irreversible growth arrest. Yet, in post-mitotic cells like neurons, the reliability of common biomarkers such as senescence-associated β-galactosidase (SA-β-gal) remains a subject of intense debate.

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Oct 17, 2025

4 min

What are the markers for senescence in the brain?

While brain aging trajectories are incredibly variable across individuals, research shows that the accumulation of senescent cells is a significant hallmark of both aging and neurodegenerative diseases. These cells, which have undergone an irreversible cell cycle arrest, are identified by a multi-marker approach, as no single marker can definitively prove senescence in the brain.

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