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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

5 min

What are the triggers of senescence? A Deep Dive into Cellular Aging

Cellular senescence, a state of irreversible cell cycle arrest, is a powerful anti-cancer mechanism, yet it paradoxically drives the aging process. The question of what are the triggers of senescence is central to understanding both disease prevention and age-related decline, involving complex cellular responses to various forms of damage.

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4 min

What is the cellular senescence theory of aging?

In 1961, Leonard Hayflick and Paul Moorhead first observed that normal human cells have a limited capacity to divide before entering an irreversible growth arrest, now known as the Hayflick limit. This discovery led to the foundational idea behind the **cellular senescence theory of aging**, which suggests that the accumulation of these dormant, non-dividing cells over a lifetime contributes to the progressive decline and disease seen with aging.

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3 min

What are the inducers of senescence?

Cellular senescence, a state of irreversible cell cycle arrest, is a fundamental process in aging. While many factors can trigger this state, a wide variety of cellular stresses are understood to be the primary inducers of senescence.

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