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Is senescence reversible? New insights challenge its irreversible nature

For decades, cellular senescence has been defined as an irreversible state of cell cycle arrest in response to stress or damage. However, a 2024 review published in *The Journal of Experimental Medicine* argues that this notion is poorly substantiated and that senescence may not be a permanent endpoint but rather a dynamic, potentially transient condition. Ongoing research into partial reprogramming and senoreverters is challenging the traditional view, revealing mechanisms that could potentially reverse this once-final cell fate.