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Can PKU start in adulthood? Understanding Adult-Onset Phenylketonuria

Phenylketonuria (PKU) is a genetic disorder typically identified through newborn screening, yet rare cases demonstrate adult-onset symptoms. It is caused by a deficiency of the enzyme phenylalanine hydroxylase (PAH), leading to a buildup of phenylalanine in the body that can cause significant health problems if untreated. The idea that **can PKU start in adulthood** challenges traditional medical understanding and highlights the importance of re-evaluating neurological symptoms in senior populations.