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Which of the following pharmacokinetic changes is most commonly observed in elderly patients?

With more than half of adults over 70 having a reduced estimated glomerular filtration rate, a progressive decline in renal function is one of the most consistently documented and clinically significant age-related changes. This decline is why reduced renal clearance is the most commonly observed pharmacokinetic change in elderly patients. These physiological alterations significantly influence how drugs are handled by the body, necessitating careful consideration in prescribing and monitoring for older adults.