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Articles related to focusing on healthy aging, prevention, mobility, cognition, nutrition, independence, and caregiving support.

2 min

What Happens When Cellular Senescence Occurs? Understanding the Double-Edged Sword

As organisms age, the number of senescent cells—which have permanently stopped dividing—increases in various tissues. Understanding **what happens when cellular senescence occurs** is critical for grasping its impact on health, including its paradoxical role in both suppressing cancer and contributing to age-related diseases.

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5 min

Exploring the Dual Roles: What Are the Benefits of Cellular Senescence?

While often associated with aging and disease, cellular senescence plays a critical, beneficial role in several biological processes, including wound healing, embryonic development, and tumor suppression. This complex process, characterized by a stable cell cycle arrest, is key to maintaining tissue integrity and preventing the proliferation of damaged cells.

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5 min

Exploring the Pathways: How Does Senescence Occur?

Did you know that normal human cells have a finite capacity to divide? This limit leads to a state called cellular senescence, and understanding exactly how does senescence occur is key to comprehending the fundamental processes of aging and age-related diseases. The process is a complex interplay of molecular events that halt cell division in response to stress.

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5 min

What are the markers of senescent macrophages?

Cellular senescence, a hallmark of aging, affects various cell types, including immune cells like macrophages. An accumulation of these non-proliferating but metabolically active senescent macrophages contributes significantly to age-related decline and chronic inflammation. But what are the specific markers that define this cellular state?

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2 min

What is senescence in disease?: Causes, Mechanisms, and Therapies

Chronic inflammation is a characteristic of many age-related diseases, and it is often driven by cellular senescence. In disease contexts, this process of irreversible cell-cycle arrest, known as senescence, transitions from a protective mechanism to a pathological one, contributing to tissue dysfunction and aggravating various age-related conditions. (Markdown OK).

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5 min

What is cellular senescence and its role in white adipose tissue?

**Globally, obesity-related metabolic dysfunction is on the rise, and a key factor lies within our fat cells.** This article explores what is cellular senescence and its role in white adipose tissue, uncovering its link to systemic metabolic issues and age-related health decline.

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3 min

Understanding the Senescence Stage of Age: From Cellular Halt to Organismal Impact

Discovered in 1961 by Hayflick and Moorhead, cellular senescence describes a state where cells permanently stop dividing after a finite number of replications, a phenomenon known as the Hayflick limit. This is the very foundation of understanding what is the senescence stage of age, a fundamental biological process deeply connected to overall health and aging.

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3 min

What triggers cell senescence? A deep dive into the cellular aging process

Cellular senescence is a state of irreversible growth arrest that cells enter when they experience certain stressors. It's a fundamental process linked to aging and many age-related diseases, and understanding what triggers cell senescence is crucial for developing therapies to extend healthspan.

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