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What is the role of melatonin in bone regeneration: A review of involved signaling pathways?

Melatonin, often associated with regulating the sleep-wake cycle, has been shown in recent studies to significantly influence bone metabolism. This multifunctional molecule plays a crucial role in bone regeneration by modulating various signaling pathways, promoting osteoblast differentiation, and suppressing bone-resorbing osteoclasts. A comprehensive understanding of this process is critical for developing new therapeutic strategies for bone degenerative diseases like osteoporosis.