:

Decoding the Cellular Clock: How is SIRT1 regulated in ageing and obesity?

Declining sirtuin activity is a hallmark of metabolic aging, and research shows SIRT1 expression and function are significantly reduced in older and obese individuals. Understanding **how is SIRT1 regulated in ageing and obesity** is crucial, as this protein acts as a key sensor linking cellular energy status to gene expression and overall health.