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Why Avoid TCA in the Elderly? A Critical Review of Risks

According to the American Geriatrics Society's Beers Criteria, tricyclic antidepressants (TCAs) are on the list of potentially inappropriate medications for older adults. The primary reasons why avoid TCA in the elderly include their high anticholinergic burden, which increases the risk of falls, cognitive impairment, and serious cardiac issues. For these reasons, healthcare providers often favor newer, safer alternatives for treating depression and other conditions in geriatric patients.