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Why is age a predisposing factor for delirium?

According to research published in *The Journals of Gerontology*, the incidence of delirium can reach up to 87% in elderly intensive care unit patients, highlighting the increased vulnerability with age. Age is a predisposing factor for delirium due to a combination of diminished physiological reserves, neuroinflammatory changes, and alterations in neurotransmitter systems, which weaken the brain's ability to cope with acute stressors.