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Which area of the brain seems to be the most affected by the aging process as far as having tangles, plaques, and widened sulci?

According to the National Institute on Aging, age is the biggest risk factor for Alzheimer's disease, and certain brain changes are considered a normal part of aging. Understanding which area of the brain seems to be the most affected by the aging process as far as having tangles, plaques, and widened sulci is crucial for both preventative care and comprehending neurodegenerative disorders like Alzheimer's.