Skip to content

What are the side effects of the new flu shot for people over 65?

4 min read

The Centers for Disease Control and Prevention (CDC) estimates that between 70-85% of seasonal flu-related deaths occur in people over 65. Understanding what are the side effects of the new flu shot for people over 65 is a key step toward making an informed decision for your health and safety. The newer, enhanced vaccines are specifically formulated to provide better protection for older adults with declining immune systems.

Quick Summary

The side effects of enhanced flu shots for people over 65 are typically mild and temporary, and may include pain, redness, or swelling at the injection site, headache, muscle aches, and fatigue. These symptoms usually resolve within a few days and are a normal sign that the immune system is building a stronger response to the vaccine.

Key Points

  • Enhanced Vaccines Recommended: High-dose, adjuvanted, and recombinant flu shots are preferentially recommended by the CDC for people 65 and older to compensate for a naturally weaker immune response.

  • Mild, Temporary Side Effects: Common side effects include pain at the injection site, headache, muscle aches, and fatigue, which typically last 1–3 days and indicate the vaccine is working.

  • Slightly More Noticeable Reactions: Enhanced vaccines may cause slightly more frequent or intense side effects than standard shots, but they remain generally mild.

  • Cannot Cause the Flu: Flu shots for seniors use inactivated viruses or lab-made viral components, so they cannot cause an influenza infection.

  • Rare, Serious Reactions: While extremely rare, serious side effects like Guillain-Barré Syndrome (GBS) can occur. The risk is much higher from the flu illness itself than from the vaccine.

  • Safety and Benefit: The proven safety and efficacy of enhanced flu vaccines mean the protection gained far outweighs the minimal risk of mild side effects.

In This Article

Why Enhanced Flu Shots are Recommended for Seniors

As people age, their immune systems naturally become less robust, a process known as immunosenescence. This can make older adults more susceptible to serious complications from the flu, such as pneumonia, which can be life-threatening. Standard-dose flu vaccines may not elicit a strong enough protective immune response in older adults. To counter this, the CDC preferentially recommends enhanced flu shots for people over 65. These vaccines are specifically designed to provoke a stronger immune reaction, providing better protection.

The Three Types of Enhanced Flu Vaccines

There are three main types of enhanced flu vaccines recommended for seniors, and understanding their differences can help you manage side effects expectations:

  • High-Dose (e.g., Fluzone High-Dose): This vaccine contains four times the amount of antigen (the part that triggers an immune response) as a standard flu shot, leading to a more robust immune system activation.
  • Adjuvanted (e.g., Fluad Quadrivalent): This vaccine includes an adjuvant, an ingredient that helps create a stronger immune response. It also contains the same amount of antigen as a standard vaccine.
  • Recombinant (e.g., Flublok Quadrivalent): This option is egg-free and does not use the flu virus in its manufacturing process, making it suitable for those with severe egg allergies.

Common Side Effects of the New Flu Shot for People Over 65

The side effects experienced with enhanced flu shots for seniors are generally similar to those from standard vaccines, but they may occur more frequently or be slightly more noticeable. This is because the enhanced formulas are more potent, which is a sign that your immune system is responding as intended. The good news is that these symptoms are typically mild and short-lived, resolving within one to three days.

  • Injection Site Reactions: The most common side effects are local and occur at the site of the injection. These include pain, tenderness, redness, and swelling.
  • Systemic Side Effects: Some individuals may experience flu-like symptoms as their body builds immunity. These can include headache, muscle aches, fatigue, and low-grade fever.

It is crucial to remember that the flu shot cannot give you the flu. The mild, flu-like symptoms are simply your immune system activating its defenses. This is a small price to pay for protection against a potentially serious illness.

Managing Side Effects

Though side effects are a normal part of the vaccination process, there are steps you can take to alleviate any discomfort:

  1. For Injection Site Pain: Apply a cool, damp cloth to the injection area. Gently moving your arm and doing some light exercise can also help to reduce soreness.
  2. For Flu-Like Symptoms: Over-the-counter pain relievers, such as acetaminophen or ibuprofen, can help with headaches, muscle aches, and fever. Consult your doctor or pharmacist to ensure these medications are safe for you.
  3. Rest and Hydrate: Getting plenty of rest and staying hydrated after your shot can help your body recover and build immunity effectively.

Comparison of Enhanced Flu Vaccine Side Effects

The frequency and type of side effects can vary slightly between the different enhanced vaccines. The following table provides a comparison based on clinical data. For more detailed information on flu vaccines, you can visit the official CDC website.

Feature Fluzone High-Dose (High-Dose) Fluad Quadrivalent (Adjuvanted)
Mechanism Contains 4x the antigen of a standard shot. Contains an adjuvant to boost immune response.
Immune Response Stronger, more robust response. Stronger, more robust response.
Common Side Effects Pain, redness, swelling at injection site; headache; muscle pain; tiredness. Pain, redness, swelling at injection site; headache; muscle aches; fatigue.
Relative Frequency of Side Effects Slightly more frequent than standard shots. Slightly more frequent than standard shots.
Manufacturing Egg-based. Egg-based, with squalene-based adjuvant.

Rare but Serious Side Effects

While extremely uncommon, it is important to be aware of the signs of a severe allergic reaction or other serious complications. The risk is very low, but symptoms requiring immediate medical attention include:

  • Difficulty breathing or shortness of breath
  • Dizziness or feeling faint
  • Hives or swelling around the face or throat
  • Seizures

A very rare side effect associated with the flu vaccine is Guillain-Barré Syndrome (GBS). The risk of developing GBS is statistically higher from the flu illness itself than from the vaccine. Healthcare professionals are trained to identify and manage any potential issues, and the overall safety record of flu vaccines is very strong.

Conclusion: Prioritizing Your Health

Understanding what are the side effects of the new flu shot for people over 65 can help you feel more confident about your annual vaccination. The mild, temporary side effects are a small price to pay for the significant protection these enhanced vaccines offer against a serious illness. The benefits, including a reduced risk of hospitalization and flu-related complications, far outweigh the risks associated with the shot. Talk to your doctor or pharmacist about which enhanced flu vaccine is the right choice for you this flu season.

Frequently Asked Questions

Yes, the Centers for Disease Control and Prevention (CDC) preferentially recommends enhanced flu vaccines for those 65 and older, such as high-dose (Fluzone High-Dose) or adjuvanted (Fluad) versions. These are specifically formulated to create a stronger, more protective immune response.

No, you cannot get the flu from an injectable flu shot. The vaccines recommended for seniors are made with inactivated (killed) viruses or lab-made viral components that are not infectious.

Studies have shown that enhanced flu shots for seniors may cause slightly more frequent or intense side effects, such as headache or muscle aches, than standard shots, but they remain generally mild and temporary.

To manage injection site soreness, you can apply a cool, damp cloth to the area. Gently moving your arm and doing some light exercise can also help. Over-the-counter pain relievers can assist with more general aches and pains.

For most people, common side effects like headache, muscle aches, and soreness resolve on their own within 1 to 3 days after vaccination.

You should contact a healthcare provider if side effects persist for more than a few days, worsen over time, or if you experience severe symptoms like difficulty breathing, high fever, or severe weakness.

The recombinant flu vaccine (Flublok) is egg-free and is one of the enhanced options recommended for adults 65 and older. It is important to discuss any allergies with your healthcare provider to determine the best option for you.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider regarding personal health decisions.