Yes, Dr. David Sinclair Maintains His Daily NMN Regimen
In the ever-evolving field of longevity research, one question remains constant for followers of Harvard geneticist Dr. David Sinclair: "Does David Sinclair still take NMN?" The answer, as confirmed in his most recent public statements and interviews from 2025, is a resounding yes. NMN, or nicotinamide mononucleotide, remains a cornerstone of his daily personal regimen. Dr. Sinclair takes a daily amount of NMN each morning, often mixed with yogurt to help with absorption. His continued use reflects his belief in its role as a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule vital for cellular energy and DNA repair that naturally declines with age.
Why NMN is Central to Sinclair's Protocol
Dr. Sinclair's advocacy for NMN is based on decades of research into the biology of aging. The core of his theory rests on the importance of maintaining high NAD+ levels. Here’s why NMN is a critical component for him:
- Replenishing NAD+ Levels: As we age, our NAD+ levels drop significantly, contributing to cellular dysfunction and the hallmarks of aging. By supplementing with NMN, which is a direct precursor, the body can more effectively replenish its NAD+ supply.
- Sirtuin Activation: Sirtuins are a family of proteins that regulate cellular health and are often called the “guardians of the genome.” Their activity is dependent on NAD+. Sinclair has long studied sirtuins, and his use of NMN is aimed at providing the necessary fuel for these longevity-associated proteins to function optimally.
- Synergy with Other Supplements: Sinclair doesn't take NMN in isolation. He strategically pairs it with other compounds for synergistic effects. His protocol includes resveratrol, which he believes helps to activate sirtuin enzymes, a process that requires the increased NAD+ provided by NMN.
The Evolution of Sinclair's Supplement Stack in 2025
While NMN has remained a constant, Dr. Sinclair’s full supplement regimen has evolved based on emerging research. In 2025, his stack reflects a continued dedication to a multi-pronged approach to longevity, targeting various cellular pathways of aging.
Key Components of Dr. Sinclair's 2025 Stack
- NMN (daily): The central NAD+ booster, taken in the morning.
- Resveratrol (daily): An antioxidant and sirtuin activator, taken with a fat source like yogurt for improved absorption.
- Trimethylglycine (TMG) (daily): Taken alongside NMN to support methylation and prevent the depletion of methyl groups, which can occur during the processing of NMN.
- Metformin (daily): A prescription drug used for diabetes that Sinclair takes in the evening to mimic the effects of fasting and trigger the AMPK pathway.
- Fisetin (daily): A senolytic compound that helps clear senescent ("zombie") cells, which accumulate with age and cause inflammation.
- Spermidine (daily): Promotes autophagy, the body's natural process of clearing out damaged cellular components.
- Taurine (daily): An amino acid added for its potential to improve mitochondrial function and overall lifespan, based on recent animal studies.
- Rapamycin (dose unknown): A prescription drug that inhibits the mTOR pathway, mimicking caloric restriction. He has mentioned taking it “on and off”.
Comparing Key Longevity Supplements
To understand the strategic nature of Sinclair's approach, it's helpful to compare NMN with other related or synergistic compounds. The following table contrasts NMN with resveratrol and TMG, highlighting their distinct roles in the longevity protocol.
| Supplement | Primary Mechanism | Sinclair's Use | Role in Longevity |
|---|---|---|---|
| NMN | A direct precursor to NAD+, boosting cellular NAD+ levels. | Taken daily, mixed with yogurt to improve absorption. | Replenishes declining NAD+ to support cellular energy production and DNA repair. |
| Resveratrol | A sirtuin-activating compound (STAC) that enhances sirtuin activity. | Taken daily with a fat source to increase bioavailability. | Activates longevity-associated sirtuin genes, which depend on sufficient NAD+ levels to function. |
| TMG (Trimethylglycine) | A methyl donor that helps prevent the depletion of methyl groups. | Taken daily with NMN. | Supports DNA methylation, a key epigenetic process, which can be affected by high NAD+ turnover from NMN. |
The Broader Context: Lifestyle Habits
Dr. Sinclair stresses that supplements are not a magic bullet and must be combined with a healthy lifestyle. His personal habits serve as a crucial foundation for his longevity efforts.
- Intermittent Fasting: He typically skips lunch, practicing time-restricted eating to activate cellular repair pathways and mimic the benefits of caloric restriction.
- Diet: His diet is primarily plant-based, with a focus on vegetables and healthy fats while minimizing sugar and processed foods.
- Exercise: A routine of both strength training and cardio, including walking, running, and weightlifting, is central to his routine.
- Cold Exposure: Incorporates cold plunges or baths, particularly after exercise, believing it can activate stress-response pathways beneficial for cellular health.
- Health Monitoring: Uses continuous glucose monitors (CGM) and gets regular blood tests to track dozens of biomarkers and assess his overall health.
Conclusion: NMN Still a Core Longevity Tool
For those wondering does David Sinclair still take NMN?, the answer is an unequivocal yes. As of 2025, the renowned longevity scientist continues his daily NMN supplementation, viewing it as a cornerstone of his strategy for boosting NAD+ levels and supporting cellular health. While his full protocol is complex and dynamic, incorporating other supplements like resveratrol and lifestyle habits such as intermittent fasting, NMN remains a consistent and central piece of his experimental regimen. However, it's important to remember that his approach is based on cutting-edge research, and individuals should always consult with a healthcare provider before making significant changes to their own supplement or health routine.
Additional Lifestyle Details
Dr. Sinclair's commitment to longevity extends beyond his supplement stack. He emphasizes sleep optimization, using a temperature-adjusting bed to improve sleep quality. Furthermore, he avoids alcohol and large amounts of meat, and practices oral hygiene habits like oil pulling. These combined strategies illustrate a holistic and constantly refined approach to extending healthspan, guided by his ongoing research.
Visit the official Sinclair Lab website for updates on his research into the biology of aging.
