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What is kidney function by age? A Comprehensive Guide

4 min read

As we age, our kidneys naturally experience a gradual decline in function, with the average glomerular filtration rate (GFR) decreasing by about 1 mL/min/1.73m2 each year after the age of 40. Understanding what is kidney function by age, including the normal benchmarks, is crucial for seniors and their caregivers to monitor health effectively and identify potential issues early on.

Quick Summary

Kidney function typically declines with age, a normal process monitored primarily by the Estimated Glomerular Filtration Rate (eGFR), which indicates how well the kidneys filter blood. This natural reduction can be accelerated by chronic conditions like diabetes and hypertension, but lifestyle factors can help support kidney health. Regular screenings are vital, as significant loss of function often shows no symptoms until advanced stages.

Key Points

  • Normal Decline: Kidney function naturally decreases with age, with the Estimated Glomerular Filtration Rate (eGFR) dropping gradually after age 40, even in healthy individuals.

  • Key Measurement: eGFR is the main indicator of kidney function, calculated from blood creatinine, age, and sex; lower numbers can suggest reduced function.

  • Underlying Causes: The decline is due to a reduced number of functioning nephrons and decreased renal blood flow over time.

  • Major Risk Factors: Conditions like diabetes and high blood pressure can significantly accelerate age-related kidney decline and increase the risk of chronic kidney disease.

  • Preventative Measures: Lifestyle choices such as maintaining hydration, regular exercise, and a kidney-friendly diet (low in sodium, balanced protein) can support kidney health.

  • Importance of Screening: Since early kidney disease often has no symptoms, annual screenings for at-risk groups (including those over 60) are critical for early detection.

  • Comprehensive Monitoring: A doctor will use multiple tests, including blood work (eGFR, creatinine) and urinalysis (albumin), for a complete picture of kidney health.

In This Article

Understanding the Kidneys

Your kidneys are two bean-shaped organs, each about the size of a fist, located on either side of your spine below the rib cage. Their main function is to filter waste products and excess fluid from your blood, which is then excreted as urine. They also perform other vital tasks, including regulating blood pressure, balancing electrolytes, producing hormones that create red blood cells, and activating vitamin D for bone health. A typical kidney contains up to a million tiny filtering units called nephrons, which are critical to this process.

How Kidney Function Is Measured

Clinicians assess kidney function using several key indicators, with the Estimated Glomerular Filtration Rate (eGFR) being the most common. The eGFR is a calculation that uses a person's blood creatinine levels, age, sex, and body size to estimate how efficiently the kidneys are filtering blood. Creatinine is a waste product from muscle breakdown, and higher levels in the blood suggest reduced kidney filtration.

Another important test is a urinalysis, which checks for protein, blood, and other substances in the urine. The presence of albumin, a type of protein, in the urine (albuminuria) can be an early sign of kidney damage, even if the eGFR is still in the normal range.

The Normal Decline in Kidney Function with Age

It is a natural part of the aging process for kidney function to decline, even in healthy individuals. This happens for several reasons:

  • Loss of Functioning Nephrons: Over time, some of the kidney's filtering units, the nephrons, simply lose their ability to function.
  • Reduced Blood Flow: Blood flow to the kidneys naturally decreases with age, impacting their filtering efficiency.
  • Changes to Glomerular Membranes: The membranes within the glomeruli (the filtering part of the nephron) can thicken, further hindering the filtration process.

Average Estimated GFR by Age Group

Age (years) Average eGFR (mL/min/1.73m²)
20–29 116
30–39 107
40–49 99
50–59 93
60–69 85
70+ 75

Note: These are average values. Individual results can vary widely based on health, lifestyle, and other factors. An eGFR under 60 for three or more months can indicate chronic kidney disease, but a lower number in a healthy older person does not always signal disease.

Chronic Conditions That Accelerate Kidney Decline

While some decrease in function is normal, several chronic health conditions can speed up this process and lead to Chronic Kidney Disease (CKD).

Diabetes

High blood sugar levels can damage the small blood vessels in the kidneys over time, leading to scarring and impaired filtering ability. This is why people with diabetes require regular kidney function screenings.

Hypertension (High Blood Pressure)

Untreated high blood pressure damages the blood vessels throughout the body, including the delicate blood vessels in the kidneys. This reduces their filtering capacity and can create a vicious cycle where damaged kidneys further contribute to high blood pressure.

Cardiovascular Disease

Heart and kidney health are closely linked. Poor circulation from heart problems, such as congestive heart failure, can affect blood flow to the kidneys, leading to decreased function.

Other Factors

Other risk factors and conditions include obesity, smoking, family history of kidney disease, and the long-term, excessive use of certain medications like NSAIDs (e.g., ibuprofen).

How Seniors Can Protect Kidney Function

Despite the natural aging process, proactive lifestyle choices can significantly support and maintain kidney health well into later years.

Lifestyle Adjustments

  • Stay Hydrated: Drinking plenty of water helps the kidneys flush out waste and toxins effectively. Older adults may experience reduced thirst, so it is important to be intentional about fluid intake.
  • Exercise Regularly: Moderate, consistent physical activity can help manage weight, blood pressure, and blood sugar, all of which are crucial for kidney health.
  • Quit Smoking: Tobacco use damages blood vessels and impairs circulation, slowing blood flow to the kidneys.
  • Limit Alcohol: Excessive alcohol consumption can raise blood pressure and put extra strain on the kidneys.

Nutritional Strategies

  • Reduce Sodium Intake: High sodium increases blood pressure and fluid retention, straining the kidneys. Limiting processed foods and salty snacks is key.
  • Control Protein Intake: For those with existing kidney issues, excessive protein can be burdensome. Consult with a dietitian to find the right balance.
  • Watch Potassium and Phosphorus: As kidney function declines, levels of these minerals can build up and cause problems. A dietitian can help create a kidney-friendly meal plan.

Medical Management

  • Regular Check-ups: Routine appointments with a primary care provider are essential for monitoring kidney health, especially for those over 60 or with existing risk factors.
  • Medication Management: Discuss all medications, including over-the-counter pain relievers and supplements, with your doctor, as some can impact kidney function.
  • Screening: Regular kidney function tests (eGFR and urinalysis) are recommended for at-risk individuals to catch problems early, as symptoms often do not appear until later stages.

Conclusion: Taking Control of Your Kidney Health

The decline in kidney function is a normal part of aging, but it is not an inevitable path toward kidney disease. By understanding what is kidney function by age and taking proactive steps, seniors can significantly influence their kidney health trajectory. Managing chronic conditions like diabetes and high blood pressure, adopting healthy lifestyle habits, and staying vigilant with regular medical check-ups are powerful strategies. Early detection through routine screening, especially for those over 60, allows for timely intervention that can help slow or prevent further damage. The journey toward healthy aging includes prioritizing the health of these vital, hard-working organs, ensuring they continue to support a high quality of life.

For more detailed information on living with and preventing kidney disease, consider exploring resources from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) available online at www.niddk.nih.gov.

Frequently Asked Questions

eGFR, or estimated glomerular filtration rate, measures how well your kidneys filter blood. It's calculated using blood creatinine levels, age, sex, and body size. Since kidney function naturally declines with age, a 'normal' eGFR for an older adult is lower than for a younger person.

Not necessarily. A lower eGFR in an older person can reflect the normal aging process and doesn't automatically mean chronic kidney disease (CKD). However, an eGFR below 60 that persists for three or more months is an indicator for CKD and warrants further medical evaluation.

Early-stage CKD often presents with no symptoms. As it progresses, signs might include fatigue, weakness, swelling in the feet and ankles, changes in urination, or dry, itchy skin. Since symptoms are subtle, regular screening is the best way to catch problems early.

A healthy diet is crucial. Limiting sodium helps manage blood pressure. For those with compromised kidney function, monitoring and possibly reducing potassium and phosphorus intake is important, as these minerals can accumulate in the blood. A balanced diet low in processed foods supports overall kidney health.

Yes, long-term or heavy use of certain nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can reduce blood flow to the kidneys and lead to kidney damage. It is important for seniors to use these medications sparingly and discuss long-term pain management with a doctor.

High blood pressure is one of the leading causes of kidney disease. It damages the blood vessels in the kidneys, decreasing their ability to filter blood effectively. Managing blood pressure is a critical step in preserving kidney function.

For those over 60 or with risk factors like diabetes, high blood pressure, or a family history of kidney disease, annual screening is recommended. Your doctor can determine the best testing frequency based on your individual health profile.

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider regarding personal health decisions.