How Often Should You Get NAD Infusions for Anti-Aging?

Oct 24, 2025 3 min read •

longevity Wellness Anti-aging

While NAD levels naturally decline with age—dropping by nearly half between youth and middle age—restoring them has been shown in animal studies to reverse metabolic conditions and improve cardiovascular function. To determine how often should you get NAD infusions for anti-aging benefits, most protocols involve an initial 'loading phase' followed by less frequent maintenance sessions.

Quick Summary

NAD infusions for anti-aging typically involve an initial intensive period, or loading phase, followed by a less frequent maintenance schedule. The optimal frequency is highly individualized, depending on factors like age, health status, and lifestyle.

Key Points

Two-Phase Protocol: The typical anti-aging regimen involves an initial loading phase to rapidly replenish NAD levels, followed by a maintenance phase to sustain them over time.
Loading Phase Frequency: For initial anti-aging effects, 1-2 infusions per week for 4-6 weeks is a common starting point.
Maintenance Frequency: After the loading phase, ongoing sessions are typically scheduled every 2-4 weeks.
Individualization is Key: The optimal infusion frequency is highly personalized, depending on age, health status, lifestyle, and treatment response.
Infusion vs. Oral Supplements: NAD infusions offer 100% bioavailability and faster results, while oral supplements are less effective due to poor absorption but are more convenient and affordable.
Side Effects: While generally well-tolerated, infusions can cause temporary side effects like nausea or flushing, which can be managed by slowing the drip rate.

Nicotinamide adenine dinucleotide (NAD) is a coenzyme critical for cellular function, energy production, and DNA repair. As we age, our natural NAD levels diminish, contributing to many age-related health issues. While NAD supplements are available, intravenous (IV) infusions are popular for anti-aging because they bypass the digestive system for higher, more consistent absorption. For those seeking to address age-related decline, the frequency of NAD infusions is typically structured in two distinct phases to maximize benefits.

The Two-Phase Approach to NAD Infusions

For anti-aging purposes, clinics commonly recommend a protocol that begins with a loading phase to rapidly increase NAD levels, followed by a maintenance phase to sustain those levels over time. A licensed healthcare provider should always supervise this process.

Phase 1: The Initial Loading Phase

This initial, more intensive period is designed to replenish depleted NAD levels and establish a robust baseline in the body's cells. For anti-aging and overall wellness, a common starting point is:

Frequency: 1–2 infusions per week.
Duration: 4–6 weeks.
Goal: Quickly restore cellular energy, promote DNA repair, and boost mitochondrial function.

Phase 2: The Ongoing Maintenance Phase

After completing the initial loading phase, the focus shifts to less frequent infusions. The exact frequency depends on an individual's response to the treatment, their lifestyle, and desired outcomes.

Frequency: Typically every 2–4 weeks.
Duration: Ongoing, as needed, to sustain benefits.
Goal: Maintain enhanced energy, cognitive function, and cellular health.

Factors Influencing Your NAD Infusion Schedule

No single schedule works for everyone. Several factors can influence how often you may need NAD infusions for anti-aging. A provider will tailor a plan based on a comprehensive assessment of your unique health profile.

Your Age and Baseline NAD Levels: Older adults often require more frequent infusions to counteract the natural, age-related decline in NAD.
Lifestyle: High stress levels, poor sleep, and a diet high in sugar and processed foods can rapidly deplete NAD, necessitating more regular treatments.
Health Goals: Individuals targeting general wellness might need fewer sessions than those seeking more intensive anti-aging benefits.
Response to Treatment: Some people metabolize NAD faster than others. A provider will monitor your response to determine the optimal interval between sessions.

NAD Infusions vs. Oral Supplements

For those considering anti-aging strategies, understanding the differences between delivery methods is essential. Infusions and oral supplements offer distinct advantages and disadvantages, primarily related to absorption and cost.


Feature	NAD Infusions (IV)	Oral NAD Precursor Supplements
Delivery Method	Directly into the bloodstream via IV line.	Ingested via pills, powders, or liquids.
Bioavailability	100% absorption, bypassing the digestive system.	Low and variable due to first-pass metabolism in the gut and liver.
Onset of Effects	Rapid, often within hours or days.	Slow, can take weeks or months to notice significant effects.
Dosing	Higher, more potent, and consistent therapeutic doses (e.g., 500-1500mg).	Lower, limited by absorption (e.g., 100-1200mg of precursors).
Convenience	Less convenient; requires in-clinic or mobile appointments lasting 1-4 hours.	Highly convenient; can be taken at home.
Cost	Generally more expensive per session ($200-$1500+).	Generally more affordable over the long term.
Side Effects	Temporary flushing, nausea, or headache possible if infused too quickly.	Mild gastrointestinal discomfort, if any.

Conclusion

Determining how often you should get NAD infusions for anti-aging is not a fixed protocol but a personalized plan best developed in consultation with a qualified healthcare provider. The standard approach involves an initial loading phase of weekly or bi-weekly infusions for about a month, followed by less frequent maintenance sessions, typically every 2 to 4 weeks. While NAD infusions offer superior bioavailability and rapid onset of effects compared to oral supplements, their higher cost and required time investment are significant considerations. Ultimately, the ideal frequency depends on your specific health goals, age, lifestyle, and individual response to therapy. With proper medical supervision, NAD therapy can be a strategic tool for those looking to support cellular health and longevity. It is also important to consider complementary lifestyle habits, such as a healthy diet and regular exercise, to maximize your results.

For further information on the cellular science behind NAD+, consider reviewing research from the National Institutes of Health (NIH).(https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/)

Frequently Asked Questions

For anti-aging purposes, a typical starting regimen, or loading phase, involves 1 to 2 infusions per week for 4 to 6 weeks.

After the initial loading phase, maintenance infusions for anti-aging are often recommended every 2 to 4 weeks to sustain NAD levels and continue the benefits.

No, NAD infusions are not a permanent solution. The benefits last for a limited time, and regular maintenance sessions are necessary to counteract the body's natural age-related decline in NAD levels.

NAD infusions are often considered more effective than oral supplements because they deliver NAD directly into the bloodstream for 100% absorption, bypassing the digestive system where much of the substance is degraded.

Your NAD infusion schedule is influenced by your age, overall health, lifestyle factors like stress and diet, and how your body responds to the treatment. A healthcare provider will tailor a plan to your specific needs.

Common side effects, which are usually mild and temporary, include flushing, headaches, nausea, or chest tightness. These often occur if the infusion is administered too quickly and can be managed by slowing the drip rate.

Yes. Overly frequent infusions are not recommended and may cause unpleasant side effects. Your healthcare provider will determine a safe and effective schedule based on your treatment goals and tolerance.

References

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider regarding personal health decisions.