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What happens if delirium is left untreated? The serious risks explained

4 min read

Did you know that delirium is unrecognized in up to 60% of cases, especially the less obvious hypoactive form? Understanding what happens if delirium is left untreated is critical, as delaying intervention can lead to a host of severe and far-reaching health consequences.

Quick Summary

Leaving delirium untreated can lead to severe consequences, including irreversible cognitive decline, increased risk of dementia, longer hospital stays, and higher mortality rates, placing a significant burden on patients and their families and underscoring its medical urgency.

Key Points

  • Irreversible Cognitive Decline: Leaving delirium untreated can lead to permanent issues with memory, thinking, and focus, often accelerating pre-existing cognitive conditions.

  • Increased Risk of Dementia: Research indicates a strong link between untreated delirium and a significantly higher risk of developing dementia in the long term.

  • Higher Mortality Rate: Delirium, particularly the hypoactive type, is associated with a higher mortality rate if not addressed and managed promptly.

  • Serious Physical Complications: Untreated delirium can cause physical harm through an increased risk of falls, aspiration pneumonia, and malnutrition.

  • Significant Burden on Care: The consequences of untreated delirium lead to longer hospital stays, greater healthcare costs, and immense emotional and financial strain on families.

In This Article

The Immediate Dangers of Untreated Delirium

When delirium is not addressed promptly, patients face a cascade of immediate risks, especially within a hospital or care facility setting. Delirium is not merely confusion; it is an indicator of an underlying medical problem that is stressing the brain. If the root cause, such as an infection, is not treated, the patient's condition can deteriorate rapidly.

Key immediate risks include:

  • Increased Risk of Falls and Injuries: Delirium significantly impairs awareness and judgment, making patients more prone to falls that can result in fractures and other serious injuries.
  • Prolonged Hospital Stays: Patients with untreated delirium often require longer periods of hospitalization, increasing their exposure to hospital-acquired complications like infections and pressure ulcers.
  • Higher Intensive Care Unit (ICU) Admissions: The risk of needing an ICU admission for higher-level care is much greater for those with delirium.
  • Aspiration Pneumonia: Impaired coordination and swallowing can lead to aspiration, where food or liquid enters the lungs, causing a severe infection.
  • Self-Removal of Medical Equipment: Patients may become agitated and attempt to remove intravenous lines, catheters, or other essential medical devices, compromising their care.

The Long-Term Consequences on Cognitive Function

Perhaps the most devastating impact of untreated delirium is the potential for long-term or even permanent cognitive damage. Accumulating evidence shows that delirium is not just a temporary state of confusion.

  1. Persistent Cognitive Impairment: Even after the delirium resolves, many patients experience persistent long-term cognitive impairment, struggling with memory, focus, and thinking skills.
  2. Increased Risk of Dementia: Research shows a clear link between delirium and an increased risk of developing dementia. A study published in JAMA Neurology found that patients who experienced delirium were more than twice as likely to show significant long-term cognitive decline.
  3. Accelerated Cognitive Decline: For individuals who already have dementia, a bout of untreated delirium can significantly accelerate the progression of their neurodegenerative process, leading to a much faster decline in cognitive function.
  4. Loss of Independence: As cognitive abilities wane, many individuals lose the capacity to perform daily tasks, leading to a loss of independence and the need for institutionalized care.

Physical Health Complications from Delayed Treatment

Beyond the immediate hospital-related issues, delayed treatment can lead to a host of physical health complications that hinder recovery and long-term well-being. The metabolic stress on the body during untreated delirium can suppress the immune system and prevent proper healing.

  • Malnutrition and Dehydration: Altered mental status and confusion can lead patients to refuse food and drink, causing malnutrition, dehydration, and serious electrolyte imbalances.
  • Increased Mortality: Studies have consistently shown that untreated delirium is associated with a significantly higher mortality rate, both in the short term and over the long term. This is especially true for the hypoactive type, which is often missed.
  • Functional Decline: Reduced mobility and physical weakness during a delirious episode can lead to long-term functional decline, making it difficult for individuals to regain their previous level of activity.

Comparing Untreated Delirium and Dementia

While they are often confused, it is crucial to differentiate between delirium and dementia, especially considering their different trajectories when untreated.

Features Delirium Dementia
Onset Acute (hours to days) Insidious (months to years)
Course Fluctuating; symptoms come and go Progressive, with slow, gradual decline
Duration Days to weeks Months to years
Consciousness Altered, with fluctuating levels Clear (until later stages)
Attention Impaired; easily distracted Normal (until severe dementia)
Reversibility Usually reversible with treatment Rarely reversible

The Ripple Effect: Emotional and Financial Strain

The consequences of untreated delirium extend beyond the individual patient, creating a significant burden on families and the healthcare system. The emotional toll of watching a loved one's personality and cognitive abilities change so dramatically and suddenly can be immense. Furthermore, the financial costs associated with longer hospital stays, increased care needs, and potential long-term care placement can be staggering.

For family members, navigating the fear, stress, and logistical challenges of caring for a delirious loved one is a significant burden. The communication breakdowns caused by delirium, coupled with personality changes, can cause considerable emotional distress and confusion for both the patient and their family. Without treatment, this stress can be prolonged and intensified.

Why Early Recognition is a Matter of Urgency

Delirium is a medical emergency that requires prompt identification and treatment of the underlying cause. Delaying intervention allows the insult to the brain to continue, increasing the risk of permanent brain injury and long-term cognitive issues. Prevention and early detection are key to mitigating the severe consequences of untreated delirium.

Healthcare providers and family members must work together to identify the sudden onset of confusion and address modifiable risk factors immediately. Interventions can include ensuring proper hydration, managing pain, maintaining a consistent sleep-wake cycle, and providing sensory aids like glasses and hearing aids. Recognizing delirium's subtle symptoms, especially in the hypoactive form, is critical for achieving better patient outcomes. For more information on why this is an urgent matter, refer to Why delirium should be treated as a medical emergency.

Conclusion

Understanding what happens if delirium is left untreated is essential for all involved in senior care. The risks are substantial, ranging from increased mortality and long hospital stays to severe, irreversible cognitive decline and the onset of dementia. While the journey through delirium can be frightening, the good news is that with prompt and targeted treatment of the underlying cause, the prognosis is far better. Early recognition and a multi-faceted approach to care are the most effective ways to prevent the most serious and lasting consequences, protecting the patient's long-term health and functional independence.

Frequently Asked Questions

Yes, if the underlying cause is not addressed, the metabolic stress on the brain can lead to persistent or even permanent cognitive impairment and injury.

While delirium can increase the risk of dementia, delirium is an acute and fluctuating state of confusion, whereas dementia is a progressive decline over months to years. Untreated delirium can worsen or even trigger the onset of dementia.

Yes, studies have shown that untreated delirium is associated with significantly higher mortality rates in both the short-term and long-term compared to patients without delirium.

Hypoactive delirium, which is often missed, is associated with higher rates of morbidity and mortality than other types. Leaving it untreated can lead to aspiration pneumonia, pressure ulcers, and a worse overall prognosis.

Untreated delirium can lead to a variety of physical harms, including falls resulting in fractures, aspiration pneumonia, pressure ulcers from immobility, malnutrition, and dehydration.

Yes, delaying treatment typically results in a longer hospital stay, which increases healthcare costs. Furthermore, the long-term functional decline may require expensive institutionalization or increased at-home care.

Yes, family members play a crucial role. They are often most familiar with the patient's baseline mental status and can help recognize acute changes. By providing reassurance and a familiar environment, they can also support prevention and treatment.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider regarding personal health decisions.