Bryan Johnson's Evolving Blueprint Protocol
Bryan Johnson's daily regimen, known as Project Blueprint, is a data-driven approach to reverse biological aging and achieve peak health. Far from being a static list, his supplement and medication stack is continuously updated based on his body's real-time biometric data, as analyzed by his team of doctors and scientists. This intensive, personalized approach distinguishes it from a standard vitamin routine and underscores why attempting to replicate it without medical supervision is not recommended.
His intake includes a variety of compounds, ranging from his own branded Blueprint supplements to specific prescription drugs used off-label for their potential longevity benefits. Recent updates to his protocol have seen a shift toward more streamlined, comprehensive products like his Blueprint multivitamins, which has reduced the total number of pills he takes daily, though the protocol remains extensive.
A Detailed Look at His Daily Pill Stack
Morning and Midday Regimens
Bryan Johnson's day begins with a significant supplement intake, typically accompanied by his first meal around 6:45 a.m. This is designed to prime his body for the day's activities. His morning and midday protocols often overlap, with specific pills taken at different times.
- Blueprint Essential Capsules: A multivitamin containing 26 nutrients, including B vitamins, vitamin D3, Ubiquinol, and Nicotinamide Riboside, aimed at supporting sleep, muscle recovery, and cognitive function.
- Blueprint Essential Softgel: Provides seven fat-soluble nutrients like vitamin K1, K2, astaxanthin, lutein, and lycopene for vision, heart, and antioxidant support.
- Blueprint NAC + Ginger + Curcumin: A combination supplement focused on combating oxidative stress, reducing inflammation, and aiding liver health.
- Blueprint Red Yeast Rice + Odor-Free Garlic: Supports healthy cholesterol levels and cardiovascular health.
- Omega-3s (EPA/DHA/DPA): A crucial part of his stack for supporting brain and cardiovascular health.
- Aged Garlic Extract (Kyolic): Used to support blood pressure and heart health.
- ProButyrate: A supplement designed to support gut health and stabilize the microbiome.
- Heme Iron Polypeptide (Proferrin): Taken to ensure healthy iron levels.
- N-Acetyl-L-Cysteine (NAC): A powerful antioxidant that supports liver detoxification.
- Metformin ER and Acarbose: Prescription medications, typically used for diabetes, that Johnson takes for their potential longevity effects on metabolic health and glucose control.
Other Prescribed Medications
In addition to the above, Bryan Johnson's protocol has included other specific medications, some addressing pre-existing conditions and others for off-label use.
- Candesartan: A prescription medication for managing high blood pressure.
- Jardiance: Prescribed to potentially reduce the risk of cardiovascular death.
- Levothyroxine & Armor Thyroid: Taken to manage a pre-existing hypothyroidism diagnosis.
- Oral Minoxidil: A medication for hair growth.
- Tadalafil: Used for blood vessel relaxation.
Why Bryan Johnson Stopped Taking Rapamycin
One of the most notable changes to his regimen occurred in early 2025 when Johnson publicly announced he had stopped taking Rapamycin, an immunosuppressant. He had experimented with it for nearly five years for its potential anti-aging benefits, which had shown promise in preclinical animal studies. However, Johnson and his team observed significant adverse side effects, including skin infections, elevated blood sugar, and an increased resting heart rate. Furthermore, a new preprint study at the time suggested Rapamycin might accelerate aging across several epigenetic clocks in humans, prompting him to discontinue it entirely. For a detailed explanation, Johnson's blog post on the topic is a key resource: Bryan Johnson's blog post on stopping Rapamycin.
Blueprint Protocol Comparison
To better understand the different components of his protocol, here is a comparison of some key pill categories.
| Category | Examples | Primary Purpose (Blueprint Context) |
|---|---|---|
| Blueprint Products | Essential Capsules, Essential Softgel, NAC + Ginger + Curcumin | Provides comprehensive daily nutrition, antioxidants, and support for cognitive, heart, and liver health |
| Foundational Supplements | Omega-3s, Creatine, Collagen Peptides | Supports brain function, cardiovascular health, energy production, muscle mass, and skin/joint health |
| Metabolic Prescriptions | Metformin, Acarbose, Jardiance | Manages blood glucose levels and influences metabolic pathways for potential longevity benefits |
| Other Prescriptions | Candesartan, Oral Minoxidil, Tadalafil | Addresses specific metrics like blood pressure, hair loss, and vascular health |
Important Considerations for Replication
Bryan Johnson's regimen is an extreme example of personal health optimization and is not a one-size-fits-all solution. Experts caution against simply copying his protocol due to the high costs and potential health risks associated with combining numerous potent substances, especially off-label medications. His protocol is built upon constant, invasive monitoring and professional medical guidance. Before considering any extensive supplement or medication regimen, it is essential to consult with a qualified healthcare provider. Focusing on the fundamentals of a healthy diet, regular exercise, and quality sleep offers a far more accessible and proven path to healthy aging for most individuals.
Conclusion: More Than Just a Handful of Pills
Bryan Johnson's answer to the question, "What pills does Bryan Johnson take daily?", is a complex and evolving regimen that extends far beyond a simple handful of vitamins. His Blueprint project represents a dedicated, data-intensive, and extremely costly endeavor into longevity science. While his personal protocol is designed to achieve a specific outcome for him, the public can learn from his commitment to health optimization. However, it serves as a powerful reminder that personalized medicine, guided by expert data analysis, is not the same as blindly following a trend.
