Who makes NMN in Japan? A Guide to Top Manufacturers

According to Business Wire, Mirailab Bioscience pioneered the commercialization of NMN supplements, launching the world's first product in 2015. This pioneering spirit is reflected in the many companies now answering the question of who makes NMN in Japan, offering a variety of high-purity, high-quality supplements and cosmetics.

Quick Summary

This article identifies major Japanese manufacturers of nicotinamide mononucleotide (NMN), detailing their reputations for quality, use of advanced production methods, and commitment to clinical research. Key companies highlighted include Mirailab Bioscience, Meiji Pharmaceutical, and Eurea, showcasing Japan's significant presence in the global NMN market.

Key Points

• Leading Manufacturer: Mirailab Bioscience is recognized as a pioneer that first commercialized NMN in 2015 and maintains a dedicated research facility.

• High-Purity Standards: Many Japanese NMN brands, including Mirailab and Meiji Pharmaceutical, are known for producing supplements with purity levels exceeding 99%.

• Advanced Manufacturing: High-quality NMN in Japan is typically produced using the enzymatic synthesis method, which yields high-purity β-NMN and is considered safe and efficient.

• Clinical Research Backing: Several Japanese companies, including Mirailab and Meiji, have conducted or participated in clinical studies to test the safety and effects of their NMN products.

• GMP Certified Production: Quality assurance is a priority for many Japanese NMN manufacturers, with products made in GMP-compliant factories under strict quality control.

• Diverse Offerings: Beyond traditional supplements, Japanese companies like Eurea offer NMN in various forms, including cosmetics, using Japanese-sourced ingredients.

• Exclusive Beta-NMN: Reputable manufacturers like Mirailab focus on producing only the biologically active β-NMN, which the body can properly utilize.

Japan has become a key player in the global market for nicotinamide mononucleotide (NMN), a compound prized for its potential anti-aging properties. Numerous Japanese companies leverage advanced biotech and strict quality control standards to produce high-purity NMN products. Among the most prominent are Mirailab Bioscience, Meiji Pharmaceutical, and Eurea, each with distinct manufacturing philosophies and product offerings.

Key Japanese NMN Manufacturers

Mirailab Bioscience: The NMN Pioneer

Mirailab Bioscience is widely regarded as a pioneer in the NMN supplement industry. The company, which was formerly known as Shinkowa Pharmaceutical, was the first in the world to commercialize an NMN supplement in 2015.

• Reputation: Mirailab has established a strong reputation for research and safety. It is the only company in Japan with a dedicated in-house NMN research facility.
• Quality and Purity: The company's NMN products often boast a purity of over 99.7% and are recognized by leading NMN researchers, including Professor Shin-ichiro Imai.
• Manufacturing Method: Mirailab emphasizes its use of the naturally occurring β-NMN type, ensuring a product that the body recognizes and can utilize effectively.
• Clinical Research: The company's NMN has been used in human clinical trials, with its safety confirmed during a 24-week study at a Japanese national university.

Meiji Pharmaceutical: The Established Conglomerate

Meiji Pharmaceutical, a well-known name in the Japanese pharmaceutical and food industry, also produces high-quality NMN supplements. The company leverages its extensive experience and brand trust to offer reliable products.

• Manufacturing Standards: Products like "NMN 15000 Plus" are manufactured under comprehensive quality control standards similar to pharmaceutical products.
• Product Ingredients: Meiji often combines NMN with other ingredients, such as resveratrol, PQQ, and coenzyme Q10, to create synergistic effects.
• Recent Research: In 2024, Meiji Holdings published findings from a human study indicating that NMN intake could improve walking speed and sleep quality in older adults.

Eurea: High-Quality, Fermentation-Based NMN

Eurea focuses on producing NMN using Japanese ingredients and manufacturing processes, with a particular emphasis on yeast fermentation.

• Manufacturing Method: Eurea's NMN is derived from yeast fermentation, which is considered a complex and high-quality process.
• Product Purity: The brand provides domestically produced, high-purity NMN, assuring consumers of its quality.
• Diverse Applications: Beyond supplements, Eurea also applies its NMN to cosmetics, highlighting the ingredient's versatility.

Comparison of Japanese NMN Manufacturers

Feature	Mirailab Bioscience	Meiji Pharmaceutical	Eurea
Company History	Pioneer of commercial NMN supplements in 2015.	Long-established pharmaceutical and food conglomerate.	Specializes in high-quality, yeast-based NMN.
Manufacturing Method	High-precision process focusing on β-NMN.	Manufactured under pharmaceutical-grade standards in domestic factories.	Yeast fermentation using Japanese ingredients.
Claimed Purity	Often cited as 99.7% or higher.	Uses high-purity domestic NMN, often 99% or more.	Produces high-quality, pure NMN.
Key Differentiator	In-house research lab and involvement in clinical trials.	Combines NMN with other functional ingredients.	Uses 100% Japanese-sourced, yeast-fermented NMN.
Product Focus	Pure NMN supplements and cosmetics.	Supplements, often combined with other nutrients.	Supplements and cosmetics.

Choosing Quality Japanese NMN

When purchasing NMN supplements from Japan, consider the following factors to ensure you are getting a high-quality product:

• Purity: Look for products with high-purity claims, ideally 99% or higher, and backed by verifiable third-party testing.
• Beta-NMN: Verify that the product contains the β-NMN molecular structure, which is the form naturally synthesized in the human body.
• GMP Certification: Good Manufacturing Practices (GMP) certification ensures that the products are manufactured to rigorous safety and quality standards. Many Japanese companies adhere to these practices.
• Manufacturer Reputation: Established companies with a history of research and transparent manufacturing, like Mirailab Bioscience, often offer more reliable products.
• Clinical Backing: Some companies, like Mirailab and Meiji, have been involved in clinical studies to confirm the safety and efficacy of their NMN, which adds another layer of assurance.

The Manufacturing Process

The most common method for producing high-purity NMN in Japan is enzymatic synthesis. This process involves using enzymes to create β-NMN with high efficiency and purity, which is considered safer and more sustainable than chemical synthesis. The raw materials can be derived from yeast, a method used by companies like Eurea. This biotech approach is one reason for the high cost and high quality of Japanese NMN products.

Conclusion

In conclusion, prominent Japanese manufacturers like Mirailab Bioscience, Meiji Pharmaceutical, and Eurea are at the forefront of NMN production. They are distinguished by their commitment to high purity, reliance on advanced manufacturing techniques like enzymatic synthesis, and, in some cases, extensive clinical research. For consumers seeking high-quality NMN supplements, these brands offer reliable, well-researched options that reflect Japan's reputation for precision and quality control.

Recommended Japanese NMN Products

• Mirailab NMN Pure Series: Known for its exceptionally high purity (99.7%) and strong research backing.
• Meiji Pharmaceutical NMN 15000 Plus: A supplement that combines high-purity NMN with other beneficial ingredients like resveratrol and coenzyme Q10.
• Eurea High-Quality NMN: Produced using yeast-fermentation and Japanese ingredients, available in both supplement and cosmetic forms.

Frequently Asked Questions

Which Japanese company is considered the pioneer of commercial NMN supplements?

Mirailab Bioscience, originally Shinkowa Pharmaceutical, launched the world's first commercial NMN supplement in April 2015 and is considered the industry pioneer.

What manufacturing method is commonly used for Japanese NMN?

The most common and preferred method in Japan is enzymatic synthesis, which uses enzymes to produce high-purity NMN. Some companies, like Eurea, utilize yeast fermentation for this process.

How can I verify the quality of NMN made in Japan?

To verify the quality, look for products that specify a high purity level (often 99% or higher), contain the naturally occurring β-NMN form, are made in GMP-certified factories, and have been mentioned in clinical studies.

Do Japanese NMN manufacturers conduct clinical research?

Yes, some manufacturers, including Mirailab Bioscience and Meiji Pharmaceutical, have conducted or funded clinical studies to confirm the safety and efficacy of their NMN products.

Is all NMN from Japan of the same quality?

No, quality can vary. While reputable brands like Mirailab, Meiji, and Eurea adhere to high standards, the market also contains products with lower purity or non-specific β-NMN content. Researching the manufacturer is crucial.

What is the significance of using β-NMN?

β-NMN is the specific molecular structure of NMN naturally synthesized and used by the body to produce NAD+. Reputable Japanese manufacturers emphasize using only this form, in contrast to chemically synthesized NMN, which may contain an inactive α-NMN component.

Are there other Japanese companies making NMN products?

Yes, aside from the major players, other brands and supplement distributors offer NMN products made in Japan, such as TOKYO SUPPLEMENT and those available through wafuu.com and dokodemo.world.