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Is there a correlation between grip strength and mortality?

4 min read

According to a 2022 meta-analysis of 48 studies, there is strong evidence of an inverse relationship between lower handgrip strength and an increased risk of all-cause mortality. This growing body of research suggests that a simple, inexpensive measurement of grip strength and mortality can be a powerful biomarker for overall health, functional independence, and longevity, particularly in older adults.

Quick Summary

Studies show a consistent inverse association between grip strength and all-cause mortality risk, with weaker grip correlating to higher mortality rates. Low grip strength can indicate underlying health issues like muscle loss, heart problems, and functional decline, affecting quality of life as people age. Improving physical fitness can increase grip strength and may reduce overall health risks.

Key Points

  • Strong correlation: Multiple studies show a significant inverse correlation, with weaker grip strength linked to a higher risk of all-cause and cardiovascular mortality.

  • Biomarker for overall health: Grip strength serves as an inexpensive and reliable biomarker for overall muscle strength, functional capacity, and biological aging.

  • Not a direct cause: A weak grip does not directly cause death; it is a symptom reflecting underlying issues such as muscle loss (sarcopenia) and declining organ health.

  • Predictive power: For predicting cardiovascular mortality, grip strength has been shown to be more effective than traditional metrics like blood pressure in some studies.

  • Implications for independence: Low grip strength is linked to frailty, increased risk of falls, and a loss of functional independence in older adults.

  • Improvement is possible: Targeted exercises, such as using hand grippers, practicing pinch grips, and performing farmers' walks, can improve grip strength at any age.

In This Article

A strong body of scientific evidence supports the idea that there is a significant correlation between grip strength and mortality. This is not because a weak handshake directly causes death, but because grip strength is a reliable and easily measured biomarker for overall muscle strength, and a decline in it can signal broader health issues. In fact, some studies have found grip strength to be an even better predictor of cardiovascular mortality than blood pressure.

The science behind the grip strength and mortality link

Research has shown that grip strength can be a proxy for overall muscle health, which is a major factor in metabolic health and long-term independence. Studies consistently demonstrate that individuals with lower grip strength, particularly in midlife and older age, have a higher risk of chronic disease, disability, and early death.

  • Sarcopenia and overall muscle loss: Sarcopenia, the age-related loss of muscle mass and strength, is strongly linked to decreased grip strength. This muscle decline is associated with reduced physical function, higher rates of falls, and greater susceptibility to illness and mortality.
  • Cardiovascular health: Multiple studies have linked lower grip strength to an increased risk of cardiovascular diseases, such as heart attack, stroke, and coronary artery disease. A stronger grip may indicate better heart health and a more robust cardiovascular system.
  • Functional independence and frailty: Grip strength is a key component of the Frailty Index, a tool used to assess vulnerability in older adults. A decline in grip strength can indicate a loss of functional independence, making daily tasks like opening jars or carrying groceries more difficult and raising the risk of falls and injury.
  • Neuromuscular function: Weaker grip strength can also reflect a decline in neuromuscular function, including nerve entrapment issues like carpal tunnel syndrome. These conditions can exacerbate muscle weakness and further impair grip.

The relationship between grip strength, disease, and lifespan

Numerous prospective cohort studies and meta-analyses have investigated the relationship between grip strength and mortality. The findings consistently show that higher grip strength is associated with lower all-cause mortality, even after accounting for other health and lifestyle factors. While the link to cardiovascular and respiratory disease mortality is particularly strong, the association with cancer mortality is less consistent and may vary by cancer subtype.

Variable Low Grip Strength Association High Grip Strength Association
All-Cause Mortality Higher risk, especially in middle-aged and older adults. Lower risk across different demographics and ages.
Cardiovascular Disease Mortality Significantly increased risk of heart attack, stroke, and related death. Stronger cardiovascular health; better predictor than blood pressure in some cases.
Cancer Mortality Evidence is mixed; some studies show a link, others do not after adjusting for confounders. Inconsistent protective effect observed in some studies; potentially less related than cardiovascular mortality.
Respiratory Disease Mortality Increased risk of death from respiratory illnesses. Better respiratory function and outcomes.
Functional Independence Increased risk of frailty and needing assistance with daily tasks. Better ability to perform everyday activities like carrying and lifting.

How to measure and improve grip strength

Grip strength is typically measured using a hand dynamometer, a device that records the amount of force a person can exert by squeezing it. The process is quick, simple, and can provide valuable health insights. The test is usually performed three times on each hand, and the best result is used for assessment. You can compare your results to normative data for your age and sex, which are readily available online.

Improving your grip strength involves a variety of exercises and can be done at any age. It's important to work on all three types of grip: crush, pinch, and support.

  • Crush exercises: These involve squeezing a stress ball or hand gripper repetitively.
  • Pinch exercises: Practice pinching a barbell plate between your fingers and thumb, holding for a set duration.
  • Support exercises: Incorporate exercises like farmer's walks or dead hangs from a pull-up bar.

General strength and fitness training also improve grip strength. Whole-body exercises like weightlifting, as well as daily activities like carrying groceries, can help.

Conclusion

In conclusion, there is a strong and consistent inverse correlation between grip strength and mortality, particularly all-cause and cardiovascular-related death. Low grip strength serves as a robust and easily measured biomarker reflecting overall muscle mass and health, which are crucial for longevity and maintaining functional independence. While it is a powerful predictor, a weak grip is a symptom, not the cause, of poor health. The good news is that grip strength can be improved with regular, targeted exercise at any age, and by focusing on overall physical fitness, you can address the underlying issues it signals. This makes routine monitoring and strengthening a valuable tool for proactive health management.

Authority link

World Health Organization - Ageing and health

Frequently Asked Questions

Not necessarily. A weak grip is a strong predictor of potential health problems, not a direct cause of mortality. It acts as a warning sign for underlying issues like sarcopenia and cardiovascular risks. Improving your overall health and fitness can increase your grip strength and reduce these risks.

Normal grip strength varies based on age, sex, and height. Typically, grip strength peaks in a person's 20s or 30s and gradually declines with age. Normal values are often compared to population-specific data to determine if a person falls within the healthy range for their demographic.

While a clinical measurement uses a hand dynamometer, you can get a rough estimate at home. One method is the 'plate pinch,' where you pinch a weight plate between your fingers and thumb. The longer you can hold it, the stronger your pinch grip is. You can also use household items like a stress ball and monitor your squeezing consistency.

You can improve your grip with specific exercises like plate pinches, farmer's walks (carrying heavy objects for distance), and dead hangs from a pull-up bar. General strength training, such as deadlifts and pull-ups, also greatly contributes to overall grip strength.

Yes, low grip strength has been linked to a higher risk of several conditions, including cardiovascular disease, type 2 diabetes, and potentially some types of cancer, though evidence varies for the latter. It is also a key marker for frailty and sarcopenia.

Yes, older adults can and should work on improving their grip strength. Even simple exercises like squeezing a stress ball or a towel can help maintain or build hand and forearm strength. Consistency is key, and it is never too late to start.

In some cases, yes. A 2015 study found that reduced grip strength predicted mortality risks more effectively than blood pressure. However, experts typically use grip strength in conjunction with other standard health markers to get a complete picture of an individual's overall health.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider regarding personal health decisions.