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What Disease Is Caused by Excessive Bone Loss?: An In-depth Look at Osteoporosis

3 min read

According to the CDC, over 10 million Americans aged 50 and over had osteoporosis in 2017–2018, the disease caused by excessive bone loss. This progressive condition weakens the skeletal structure, increasing the risk of serious fractures and affecting quality of life.

Quick Summary

The disease caused by excessive bone loss is osteoporosis, a condition characterized by weakened and brittle bones that are more susceptible to breaking from a minor fall or even a simple action.

Key Points

  • Osteoporosis Defined: Excessive bone loss leads to osteoporosis, a condition where bones become porous, weak, and highly prone to fracture.

  • Silent Symptoms: Often called a "silent disease," osteoporosis typically shows no symptoms until a fracture occurs. Signs can include height loss, stooped posture, and back pain.

  • Risk Factors Vary: Risk can be influenced by non-modifiable factors like age, gender, and genetics, as well as modifiable factors such as diet, exercise, and smoking.

  • DEXA Scan Diagnosis: The gold standard for diagnosis is a DEXA (bone density) scan, which provides a T-score indicating bone health and fracture risk.

  • Prevention and Management: A strategy including adequate calcium and vitamin D, weight-bearing exercise, and fall prevention is crucial for managing the condition and reducing fracture risk.

  • Treatment Options: Treatments range from lifestyle changes to powerful medications like bisphosphonates and bone-building drugs, which can help slow bone loss.

In This Article

Understanding the Silent Threat: What is Osteoporosis?

Your bones are living tissues constantly undergoing remodeling. In youth, new bone production outpaces breakdown, increasing bone mass until peak bone mass around age 30. With osteoporosis, bone loss exceeds new bone formation, reducing bone mass and density, making the internal structure porous and fragile. It is often symptomless until a fracture occurs.

The Difference Between Osteopenia and Osteoporosis

Both involve low bone density, but osteopenia is an intermediate stage with bone density lower than normal but not yet classified as osteoporosis.

Feature Osteopenia Osteoporosis
Bone Mineral Density (T-Score) Between -1.0 and -2.5 -2.5 or lower
Bone Fragility Bones are weaker than normal, but not as porous as with osteoporosis. Bones are highly porous and brittle, significantly increasing fracture risk.
Risk Level Increased risk of developing osteoporosis; fracture risk is elevated but lower than with osteoporosis. High risk of fragility fractures from minor impacts.
Management Focus Slowing bone loss through diet and exercise to prevent progression. Preventing fractures and managing symptoms through a combination of lifestyle changes and medication.

Early detection of osteopenia through screening is vital for preventing osteoporosis.

Understanding the Causes and Risk Factors

Osteoporosis development is influenced by non-modifiable and modifiable factors.

Non-modifiable risk factors

  • Age: Risk increases as bone loss accelerates after the 20s.
  • Gender: Women, especially post-menopause due to estrogen decline, are at higher risk.
  • Race: Higher risk for those of White or Asian descent.
  • Family history: Genetic predisposition increases risk.
  • Body frame: Small-bodied individuals have less bone mass initially.

Modifiable risk factors and secondary causes

  • Nutrient intake: Insufficient calcium and vitamin D weaken bones.
  • Activity level: Sedentary lifestyles lead to weaker bones.
  • Substance use: Smoking and excessive alcohol negatively impact bone density.
  • Medications: Certain drugs, like corticosteroids, can speed up bone loss.
  • Medical conditions: Diseases like celiac disease or rheumatoid arthritis are linked to higher osteoporosis risk.

How is Osteoporosis Diagnosed?

Diagnosis often follows a fracture due to its silent nature. However, tests can detect it earlier.

  • Bone Density Test (DEXA Scan): The standard test measures bone density at the hip and spine, providing a T-score compared to a healthy young adult.
  • Physical Exam: Assessment of risk factors and physical signs like height loss.
  • Blood and Urine Tests: Used to identify potential secondary causes of bone loss.
  • Fracture Risk Assessment Tool (FRAX Score): Predicts 10-year fracture risk using DEXA results and other factors.

Treatment and Management Strategies

Management aims to slow bone loss, strengthen bones, and prevent fractures.

Lifestyle modifications

  • Diet: Consume adequate calcium and vitamin D through food or supplements.
  • Exercise: Weight-bearing and resistance exercises stimulate bone growth and improve balance.
  • Avoid Smoking and Excessive Alcohol: These habits harm bone density.

Medication

Medications either slow bone breakdown or stimulate new bone formation.

  • Bisphosphonates: Common treatments that reduce bone breakdown, available orally or intravenously.
  • Denosumab (Prolia): An injectable medication that prevents bone fragility.
  • Bone-building medications: Used for severe cases to stimulate new bone growth.

Living Well with Osteoporosis: Prevention and Safety

Preventing falls is crucial as they are a major cause of osteoporotic fractures.

  • Home Safety: Modify your home to reduce fall hazards.
  • Balance and Exercise: Exercises like Tai Chi and personalized physical therapy improve stability.
  • Supportive Footwear: Wear shoes that provide good traction.

A comprehensive approach involving lifestyle, screenings, and treatment helps manage osteoporosis. For more resources, visit the Bone Health & Osteoporosis Foundation.

Conclusion

Osteoporosis, caused by excessive bone loss, is preventable and manageable. Understanding its progression, identifying risk factors, and adopting a proactive approach with screenings, nutrition, exercise, and medication are key to protecting bone health and reducing fracture risk for an active life.

Frequently Asked Questions

While osteoporosis is the most common disease directly caused by excessive bone loss, other conditions can lead to secondary osteoporosis. These include certain cancers (like multiple myeloma), endocrine disorders (e.g., hyperthyroidism), and autoimmune diseases (e.g., rheumatoid arthritis), all of which can contribute to significant bone loss.

While it is difficult to completely reverse bone loss, modern medications can help rebuild bone or significantly slow down the rate of bone breakdown. Combined with a healthy diet and targeted exercise, treatment can increase bone mineral density and greatly reduce the risk of fractures.

It is normal to lose some bone mass with age, but a DEXA scan can determine if your bone loss has crossed the threshold into osteopenia or osteoporosis. Screening is typically recommended for women over 65 and men over 70, or earlier if you have significant risk factors.

A fragility fracture is a broken bone that results from minimal trauma, often a fall from a standing height or less. With osteoporosis, bones are so weak that a minor incident, like a simple sneeze or twist, can cause a serious break, most often in the hip, spine, or wrist.

Recommendations vary by age and gender. Generally, adults need 1,000 to 1,200 mg of calcium and 600 to 800 IU of vitamin D daily. Your healthcare provider can help determine the right amount for you and whether supplements are necessary.

Weight-bearing exercises, which force your body to work against gravity, are most effective. Examples include walking, running, dancing, and climbing stairs. Resistance exercises, like lifting weights, also help strengthen bones and muscles.

Yes, like all medications, osteoporosis treatments can have side effects. Bisphosphonates can cause stomach upset, while more serious but rare side effects include jawbone problems or atypical fractures. It is important to discuss potential side effects with your doctor to find the right treatment.

No, it is not an inevitable part of aging. While risk increases with age, building strong bones in youth and maintaining a bone-healthy lifestyle throughout your life can significantly reduce the risk of developing osteoporosis.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider regarding personal health decisions.