The Science of Supercentenarians
Reaching the age of 106 places an individual in a very exclusive group of the oldest living people, known as supercentenarians. The scientific community has long studied these remarkable individuals to uncover the biological and environmental secrets of extreme longevity. Research shows that while genes play a significant role, particularly in delaying age-related diseases, lifestyle and environment are also critical determinants. Many supercentenarians exhibit a phenomenon known as 'compression of morbidity,' meaning they remain free of major chronic diseases until the final years of their very long lives.
The Genetic Advantage
Genetic predisposition is a key factor in reaching advanced ages like 106. The New England Centenarian Study has shown that the role of genetics in longevity increases with age.
- Protective Variants: Genomic studies have identified specific genetic variants that protect against age-related diseases. Genes like STK17A (increased expression) and COA1 (reduced expression) have been linked to improved DNA repair and a lower level of somatic mutations.
- Cellular Resilience: Researchers have found that certain tissues, like the cerebellum, are exceptionally protected from aging effects in supercentenarians. This resilience helps maintain function and potentially explains why some avoid neurodegenerative diseases.
Critical Lifestyle Factors
While genetics can give a head start, daily habits are what often enable a person to fully capitalize on their inherent potential for long life.
- Diet: Many centenarians and supercentenarians follow a diet rich in fruits, vegetables, whole grains, and legumes, often resembling the Mediterranean diet. A lower-calorie intake and controlled salt are also common themes. Some also exhibit unique, individualistic dietary habits, like the Japanese supercentenarian who enjoyed coffee and sweets, or an Italian who famously ate raw eggs.
- Physical Activity: Consistent, moderate physical activity throughout life is almost universally practiced by the extremely long-lived. This includes gardening, walking, or regular exercise to maintain muscle mass, bone density, and cardiovascular health.
- Social Connections: Strong social relationships and a sense of community are consistently linked to better health outcomes and longevity. Isolation and loneliness are considered as detrimental to health as smoking.
- Stress Management: Managing stress through positive thinking, meditation, or a purposeful life is another common trait among centenarians. Many report a positive outlook and avoidance of unnecessary stress.
- No Smoking: Not smoking is a significant predictor of longevity, as tobacco use promotes chronic inflammation and other deadly diseases.
The Role of Environment
Environment plays a role that is sometimes more significant than genetics alone. Studies have observed a link between specific environments and longevity.
- Blue Zones: Research on regions known as "Blue Zones," such as Okinawa (Japan) and Sardinia (Italy), reveals that a combination of diet, physical activity, and social environment contributes to a higher concentration of centenarians.
- Socioeconomic Status: Studies have also found correlations between higher socioeconomic status, access to resources, and longer life expectancy. This reflects the impact of overall living conditions and access to quality healthcare.
Comparison of Centenarian vs. Supercentenarian Traits
| Feature | Typical Centenarian (100-109) | Supercentenarian (110+) |
|---|---|---|
| Genetics | Genetic factors contribute, but lifestyle is equally impactful. | Stronger genetic predisposition is more evident, with notable resilience and cellular protection. |
| Health Status | Often delay the onset of age-related illnesses until much later in life. | Exhibits extreme compression of morbidity, remaining disease-free until shortly before death. |
| Incidence | While still rare, the number of centenarians is rising rapidly due to advances in healthcare and living standards. | Far rarer, achieved by only about 1 in 1,000 centenarians. The number is increasing, but remains extremely low. |
| Gender Balance | More women than men, but the gender gap is not as extreme as with supercentenarians. | Overwhelmingly female; women outnumber men by a significant margin in this age group. |
| Lifestyle Habits | Good habits like diet and exercise are common. | Maintains and often intensifies healthy habits, with social and mental well-being being highly prioritized. |
| Environmental Factors | Benefits from improved healthcare, sanitation, and living conditions that have increased overall life expectancy. | Sometimes found in isolated or specific regions with traditional, healthy lifestyles, such as Blue Zones. |
Conclusion
The possibility of living to 106 is a testament to the complex interplay of genetic inheritance, consistent healthy lifestyle choices, and favorable environmental conditions. While exceptionally rare, documented supercentenarians like Ethel Caterham, who celebrated her 116th birthday, prove that such extreme longevity is within the bounds of human potential. Their stories provide valuable insights, suggesting that while we cannot change our genes, a combination of regular exercise, a balanced diet, robust social connections, and stress management significantly improves our chances not only of living longer, but of doing so in good health. [The New York Times: https://www.nytimes.com/2024/01/04/well/live/live-longer-health.html]
References
- Supercentenarian - Wikipedia. (n.d.). [Online] Available at: https://en.wikipedia.org/wiki/Supercentenarian
- 106-year-old WWII nurse donates bullet from husband's heart to Pearl Harbor museum. (2025, September 27). New York Post.
- 'Sharp as a tack' 106-year-old man reveals secrets for longevity. (2022, February 4). New York Post.
- Interesting Facts About “Supercentenarians” - Right at Home. (n.d.). [Online] Available at: https://www.rightathome.net/boston-metro-west/blog/interesting-facts-about-supercentenarians
- Is longevity determined by genetics? - MedlinePlus. (2022, July 11). [Online] Available at: https://medlineplus.gov/genetics/understanding/traits/longevity/
- Summary of What's Known » New England Supercentenarian Study. (n.d.). [Online] Available at: https://www.bumc.bu.edu/supercentenarian/summary-of-what%E2%80%99s-known/
- We reviewed the health habits of centenarians. These 4 things could lead to a longer life. (2024, August 12). The Conversation.
- Blue Zones Diet: Food Secrets of the World's Longest-Lived People. (2020, July). Blue Zones.
- The World's Longest Lived - SuperAgers. (n.d.). [Online] Available at: https://gero.usc.edu/cga/superagers/the-worlds-longest-lived/
- Emma Morano - Wikipedia. (n.d.). [Online] Available at: https://en.wikipedia.org/wiki/Emma_Morano
- National Centenarian's Day: 7 common habits of the world's longest living people. (2024, September 22). Times of India.
- The 7 Keys to Longevity. (2024, January 4). The New York Times.
- A 106-year-old who gardens every day gives her advice for living a long, healthy life. (2023, December 18). Business Insider.
- 9 Habits That'll Help You Live to 100, According to Longevity Experts. (2025, September 22). Real Simple.
- These 9 Factors Contribute to a Longer Life, Study Says. (2025, February 27). Real Simple.
- The inexorable rise of centenarians and supercentenarians. (n.d.). [Online] Available at: https://www.ined.fr/en/everything_about_population/demographic-facts-sheets/focus-on/the-inexorable-rise-of-centenarians-and-supercentenarians/
- Longevity: 8 habits can add 24 years to lifespan, new study finds. (2023, July 25). Medical News Today.
- Definition, History, and Factors Affecting Longevity - Fountain Life. (n.d.). [Online] Available at: https://www.fountainlife.com/blog/what-is-longevity
- World's oldest living person celebrates 116th birthday. (2025, August 21). ABC News.
- List of the verified oldest people - Wikipedia. (n.d.). [Online] Available at: https://en.wikipedia.org/wiki/List_of_the_verified_oldest_people
- Oldest people - Wikipedia. (n.d.). [Online] Available at: https://en.wikipedia.org/wiki/Oldest_people
- Unveiling the Secret: The World's Oldest Man Ever - Salem State Vault. (2025, July 18). [Online] Available at: https://www-backup.salemstate.edu/oldest-man-ever